Patient-Specific Planning for Thermal Magnetic Resonance of Glioblastoma Multiforme

Thermal intervention is a potent sensitizer of cells to chemo- and radiotherapy in cancer treatment. Glioblastoma multiforme (GBM) potential clinical target, given the cancer’s aggressive nature resistance current treatment options. This drives research into optimization algorithms for planning as well radiofrequency (RF) applicator design delivery. In this work, nine clinically realistic GBM target volumes (TVs) thermal are compared using three up ten RF designs magnetic resonance. Hyperthermia (HTP) was successfully performed all cases, including very small, large, even split volumes. Minimum requirements formulated metrics assessing HTP outcome were met exceeded patient specific cases. Results indicate 16 channel two row arrangement be most promising. TVs with small extent cranial–caudal direction conjunction large radial remains challenging despite advanced used. general, deep seated targets favorable. Overall, our findings that one-size-fits-all might not ultimate approach hyperthermia brain tumors. It stands reason modular reconfigurable configurations best suit needs targeting individual geometry.